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ALZHEIMER'S DISEASE

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Recent and determining scientific discoveries

Alzeimer's disease in short

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1999-2000 (1)

Nervous cells in culture treated by testosterone secrete less amyloidogenic peptides.

Conclusion of this study: androgens could be a protection against the development of Alzheimer's disease (1).

2001 (2)

The first clinical description of the increase in the blood of the β-amyloid protein rate was published in 2001 by a research team of the University of Western Australia in Perth (2). They showed that chemical castration causes the collapse of the plasmatic oestradiol and testosterone rate in man in parallel to the rise in the β-amyloid-protein.

Chemical Andropause and Amyloid- β-Peptide
(JAMA. 2001;285:2195-2196)

Andropause, Alzheimer et peptide amyloïde B

Figure. Plasma Concentrations of Amyloid- Peptide (A), Testosterone, and 17-Estradiol From 6 Men With Adenocarcinoma of the Prostate. Plasma concentrations were determined serially on samples drawn 1 week prior to initiating treatment with flutamide and leuprorelin acetate and on weeks 4, 12, and 24.

Conclusion of this study: the hormonal replacement can prevent or delay Alzheimer's disease in man with andropause.

2004 (3)

In 2004 researchers of the University of Southern California studied the testosterone content of brains in deceased.men. Two groups were studied.
The first group did not present any neuropathologic anomaly (control group).
The second group presented an Alzheimer's disease or moderate neuropathologic troubles

Conclusion of this study: the cerebral tissue of patients with Alzheimer's disease significantly contains less testosterone than cerebral tissue of men not presenting a neurophysiological anomaly (3)

2006 (4)

A clinical study was made during two years by the researchers of the Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, the USA. by a double blind study on 16 men presenting an Alzheimer's disease compared to 22 men without neurological problems, all treated by testosterone.

Conclusion of this study: the quality of life of the men presenting an Alzheimer's disease treated by testosterone was improved in general. The testosterone had a minimal effect on cognition (4)

2008 (5)

Emily R. Rosario et Christian J. Pike from the Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089 USA publish a revue of scientific publications on Alzheimer's disease.. Download pdf. (5)

Conclusions of this revue :

Alzheimer's disease shows an abnormal accumulation of amyloid protein β in the brain.
Recent studies suggest the regulating action androgens on the amyloid protein β and on development of Alzheimer's disease.
Therapy with androgens can be planned to prevent and treat Alzheimer's disease.

2011 (6)

An article of American Academy of Family Physicians raises contradictions of the treatment of Alzheimer's disease with testosterone (6).

2015 - 2016 (8)

Androgen Deprivation Therapy as treatment for prostate cancer increases the Future Alzheimer’s Disease Risk (8)

download pdf.

This publication was presented by searches from : the Stanford University; the Stanford University School of Medicine, Stanford; the University of Pennsylvania Perelman School of Medicine, Philadelphia, PA; and the School of Medicine at Mount Sinai, New York, NY.

The disappointment of immune treatments pdf.

What are the pathological lesions of the brain in Alzheimer's disease?

What can be the mechanism of this degeneration?

Testosterone production decreases with age in men and women

The chain of production of androgens in humans

Hopes that will not be disappointed to prevent Alzheimer's disease

Preventing and curing aging diseases

Bibliography

History of andropause disease	Life maintenance system	A foundation of life maintenance system	Health in XXI^st century