Immunity disorders, Sida and cancers

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It is obvious that vaccination for covid 19 of elderly people is not going to transform their dilapidated structures into normal organic structures at age 25.

This explains the deaths despite vaccination.

Urgent : SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE2

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Testosterone stimulates immunity (1-2-3). The reduction in the secretion of androgens induces the reduction in the production of lymphocytes supporting the appearance of infections and cancers.

In 2009 a publication shows the lengthening of lymphocytes telomeres under the influence of the androgens (5).(download pdf.)

The protective action of androgens on white blood cells of positive HIV men (reduction of the cellular destruction from 34 to 52%) was already shown in 1997. ( download pdf.) (4). This study suggest that the use of anabolic drugs for the treatment of AIDS-associated wastingsyndrome would not only improve their general and nutritional condition, but might also prevent the loss of CD4+T-cells through an inhibition of apoptosis.

Therapy with androgens can be of high importance among patients suffering from the AIDS when they are weak, stressed and deprived of lymphocytes (4)

Interféron-α AND testostErone

Interferon-α is used as therapy in certain cancers and chronic hepatitis. This very effective treatment has a side-effect decreasing considerably the production of testosterone (6) (download pdf.) and causing a nervous breakdown.

InterfEron-α testostErone AND KAPOSI'S DISEASE

In 1997 a study of patients carrying HIV and treated whith interferon-α shows that patients in complete remission of Kaposi's disease recover after treatment, the rates of serum androgens comparable with the rates before to the treatment whereas during the treatment with interferon-α these rates decrease considerably (7) (download pdf.).

Questions remain outstanding. It would be interesting to remake the study by determining the production of the androgens among patients carrying HIV and treated with interferon-α by the pool of androgens study. Daily production of androgens could be insufficient among patients who present a repetition or recurring repetitions of the Kaposi's disease what it impossible to show with the simple study of androgens'serum rates.

Bibliography

1. SCHUURS A.H.W.M. and VERHEUL H.A.M. -Effects of Gender and Sex Steroids on the Immune Response : J. Steroid Biochem., 35 ; 2 : 157-172, 1990

2. AHMED S.A., PENHALE W.J. and TALAL N. -Sex Hormones, Immune Responses, and Autoimmune Diseases : AJP -121, 3 : 531- 551, 1985.

3. SASSON S. and MAYER M. -Antiglucocorticoid Activity of Androgens in Rat Thymus Lymphocytes : Endocrinology, 108 : 760-766, 1981.

4. Klein SA, Klauke S, Dobmeyer JM, Dobmeyer TS, Helm EB, Hoelzer H, Rossol R. Johann Wolfgang Goethe Universität Frankfurt, Medizinische Klinik III, Frankfurt, Germany.Substitution of testosterone in a HIV-1 positive patient with hypogonadism and Wasting-syndrome led to a reduced rate of apoptosis.Eur J Med Res. 1997 Jan;2(1):30-2.

6.E P M Corssmit, E Endert, H P Sauerwein and J A Romijn: Acute effects of interferon-α administration on testosterone concentrations in healthy men. European Journal of Endocrinology (2000) 143 371-374

7.Névena Christeff, Shahin Gharakhanian, Nicole Thobie, Edith Wirbel, Marie Therese Dalle, Dominique Costagliola, Emmanuel A Nunez, Willy Rozenbaum : Effect of interferon on high serum androgenconcentrations in HIV positive men with Kaposi's sarcoma. J Clin Pathol 1997;50:341-345

WEB Bibliography

5.Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Download pdf.

Constantine A. Stratakis and Neal S. Young, Rodrigo T. Calado, William T. Yewdell, Keisha L. Wilkerson, Joshua A. Regal, Sachiko Kajigaya,

From bloodjournal.hematologylibrary.org by guest on October 22, 2012. For personal use only.

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